Proliferative Activity and Apoptosis in Thymic Epithelial Neoplasms
نویسندگان
چکیده
منابع مشابه
Well-Differentiated Thymic Epithelial Neoplasms (Thymoma)
(atypical thymoma); and those showing total loss of the organotypical features of the thymus and displaying overt cytologic evidence of malignancy correspond to high-grade or poorly differentiated thymic epithelial neoplasms (also designated, by convention, thymic carcinoma) (2,4). The grading is based on a combination of architectural and cytological parameters as observed on routine microscop...
متن کاملCurrent chemotherapy options for thymic epithelial neoplasms.
Thymomas and thymic carcinoma are rare neoplasms. Surgical resection is the cornerstone of effective therapy. Stage I disease is effectively treated by complete surgical resection. The role of radiation therapy in completely resected stage II disease remains controversial. Adjuvant radiation therapy is useful for local control and may improve survival in patients with incompletely resected tumo...
متن کاملPrognostic value of CD44 isoform expression in thymic epithelial neoplasms.
BACKGROUND Many histologic classifications of thymic epithelial tumors have been reported to date, but to the authors' knowledge, none of them closely reflect the clinical behavior or prognosis of the tumor. Therefore, it is necessary to establish a biologic marker for thymic epithelial tumors. Variants of CD44 may be important in promoting tumor progression and metastasis. Accordingly, the exp...
متن کاملImmunohistochemistry in the diagnosis of thymic epithelial neoplasms.
The diagnosis of thymic epithelial neoplasms is normally rendered after careful evaluation of their histologic features. In some cases, however, the morphological heterogeneity or overlap with neoplasms of other organ systems can lead to diagnostic uncertainty. On the basis of this, the use of immunohistochemical stains as a diagnostic adjunct has become a popular tool. Although undoubtedly, im...
متن کاملPrognostic significance of CD44v5 expression in human thymic epithelial neoplasms.
BACKGROUND Cell surface glycoproteins of the CD44 family play roles in cell-cell and cell-matrix interactions. Their aberrant expression has been implicated in tumor invasion and metastasis of a variety of neoplasms, but not, to date, of thymic epithelial tumors. METHODS To investigate the expression of CD44 molecules, immunohistochemical staining using monoclonal antibodies against human CD4...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2002
ISSN: 0893-3952,1530-0285
DOI: 10.1097/01.mp.0000038463.67854.84